Advice from our team: After cleansing your face, take a Manyo Bifida Biome Ampoule Pad and gently pass it over your entire skin, avoiding the eye contour. Use the textured side for gentle exfoliation, then the smooth side to hydrate and soothe. Do not rinse. Use morning and/or evening according to your skin's needs. Carefully close the lid after use to preserve the freshness of the pads.