MEDICUBE PDRN Pink Collagen Capsule Cream — Crème Capsules Régénérante

This cream combines a patented encapsulation technology with a synergy of highly concentrated regenerating active ingredients.

Salmon PDRN (Sodium DNA) — DNA fragments extracted from salmon sperm, structurally compatible with human DNA. PDRN stimulates the skin barrier and promotes cell regeneration, visibly reducing spots and uneven skin tone. The pink capsules protect this fragile active ingredient until contact with the skin, maximizing its absorption.

Salmon Egg Extract (Salmon Egg Extract) — A natural source of EGF (epidermal growth factor), this active ingredient signals cells to produce collagen and accelerate epidermal renewal. Combined with PDRN, it forms a regenerating duo favored in Korean clinical protocols.

Niacinamide (Vitamin B3) — Listed third in the INCI, this NAD+ precursor brightens pigmentation spots, evens skin texture, and strengthens the lipid barrier. In synergy with glutathione and thioctic acid (alpha-lipoic acid), it provides powerful antioxidant action.

5 molecular weights of hyaluronic acid — Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate. Each form targets a different depth: from the hydrating surface film to low molecular weight molecules that penetrate the epidermis for long-lasting plumping.

4-peptide complex (Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Palmitoyl Hexapeptide-12) — Amino acid chains that stimulate collagen and elastin synthesis, smooth fine lines, and improve firmness. Copper Tripeptide-1, in particular, promotes healing and tissue repair.

Ceramide NP + Moringa Oil + Cyanocobalamin (B12) — Barrier repair trio. Ceramide NP restores intercellular lipid cement, moringa oil nourishes without greasiness, and vitamin B12 soothes redness.

☀️ Morning routine

1. After your serum (or essence), take a mix of transparent gel and pink capsules on the back of your hand. For oily skin : ratio 2 gel + 1 capsule. For normal to combination skin : ratio 1:1. For dry or mature skin : ratio 1 gel + 2 capsules.
2. Gently crush the capsules between your fingers — they burst and release fresh PDRN upon application, ensuring maximum effectiveness.
3. Apply to face and neck by tapping to aid absorption. The texture blends in without a greasy film, ideal under makeup or sunscreen.

🌙 Evening routine

1. Same protocol as in the morning, but you can increase the proportion of capsules for a more intense nighttime regenerating effect.
2. Leave on overnight: PDRN works in synergy with the skin’s natural repair cycle (peak between 11 p.m. and 2 a.m.).

The 55 g jar lasts about 2 to 3 months depending on the amount used and the chosen ratio.

This capsule cream adapts to a variety of skin profiles.

• Mature skin (35 years and older) : PDRN and peptides target loss of firmness, sagging, and established wrinkles. The results are gradual but measurable.
• Uneven complexions, post-acne spots, or hyperpigmentation : the trio of niacinamide + glutathione + thioctic acid visibly brightens dark areas after 2 weeks of regular use.
• Dehydrated skin or weakened barrier : the 5 forms of HA + ceramide NP replenish the water reserve and protect against aggressors (pollution, dry climate).
• Fans of customizable skincare : you adjust the texture and intensity daily according to your skin’s needs (stress periods, hormonal cycle, seasonal changes).
• Sensitive or acne-prone skin : non-comedogenic and gentle formula, dermatologically tested, fragrance-free. Suitable even for reactive epidermis.

To avoid if : known allergy to salmon-derived products or marine derivatives. In case of active dermatological treatment (isotretinoin, recent peels), consult your dermatologist before use.

Clinical study conducted by the Global Institute of Dermatological Sciences on a user panel :

• Immediately : +102.4% skin hydration after a single application, sensation of freshness and instant comfort.
• After 2 weeks : 19.4% improvement in uneven skin tone, 1.5% reduction in pigmentation, 33% increase in elasticity.
• After 4 weeks : visibly firmer skin, refined skin texture, “glass skin” radiance without makeup effect.

The encapsulation technology ensures that PDRN remains stable and active until the moment of application—unlike conventional formulas where fragile actives oxidize in the bottle. You control the intensity of the treatment daily, a rare luxury in conventional creams.

Optimal results with twice-daily use for at least 8 weeks. Benefits are maintained with regular use.

How to precisely dose the capsules compared to the gel?

For oily skin: 2 parts gel + 1 part capsules. For normal/combination skin: 1:1 ratio. For dry/mature skin: 1 part gel + 2 parts capsules.You can adjust according to the season or your skin condition. In summer or humid climates, favor more gel. In winter or after a long-haul flight, increase the capsules for more nourishment.

Is topical PDRN as effective as injections?

Injectable PDRN (administered in clinics) penetrates directly into the dermis and offers faster and more intense results. Research on PDRN has mainly focused on injectable forms because it is a large molecule that struggles to penetrate the skin. Topical effects are therefore milder.However, MEDICUBE’s patented encapsulation optimizes absorption and allows for gradual action, ideal for daily maintenance and prevention. This cream does not replace a clinical protocol but effectively complements your anti-aging routine.

What is the difference with the PDRN Pink Peptide Serum from the same line?

The serum (10,000 ppm PDRN) is an aqueous concentrate to apply before the cream, targeting elasticity and spots intensely. The capsule cream combines PDRN + multi-layer hydration (5 HA) + barrier protection (ceramide) in a customizable final emulsion. If you want maximum effect, layer them: serum first, then cream. Otherwise, the cream alone is enough for full benefits.

Do the pink capsules keep well in the jar?

Yes, that’s precisely the innovation: the encapsulation technology preserves the firming and hydrating effect of PDRN until it is absorbed into the skin, ensuring maximum glass glow results.Always close the jar tightly after use and store away from direct light. Shelf life after opening: 12 months.

Can I use this cream if I am pregnant or breastfeeding?

The formula contains neither retinoids nor ingredients contraindicated during pregnancy. However, since PDRN is a relatively new active ingredient in topical cosmetics, studies on its use during pregnancy are limited. As a precaution, consult your doctor or midwife before use.

Is the cream suitable for the eye contour area?

Yes, the soft and non-irritating texture allows application around the orbital area. Gently tap without pulling the skin. For a targeted de-fatiguing effect, favor a gel-rich ratio (cooler, less occlusive).

MEDICUBE is a Korean brand founded by Kim Byung-hoon in 2014, owned by APR Corp. Its name merges "medicine" and "cube," embodying a cubic (targeted, structured, modular) approach to at-home dermatological care. The idea: to bring medical-grade care into daily beauty routines, without prescriptions or clinic visits.

Founded by experts in dermatology and skincare, MEDICUBE's philosophy was clear from the start: to develop products that are both safe and highly effective. All products are developed and manufactured in South Korea, clinically and dermatologically tested. The brand has physical stores in Seoul (Hongdae, Gangnam, Seongsu) where customers can try high-tech beauty devices and receive personalized skin diagnostics.

In 2024, APR Corp went public, and Kim Byung-hoon's 31% stake in the $4 billion company is worth about $1.3 billion. MEDICUBE has established itself globally thanks to its beauty devices (Booster Pro, ATS Air Shot) and PDRN formulas, endorsed by Hailey Bieber, Kylie Jenner, and millions of users. According to Bloomberg, MEDICUBE is now the No. 1 K-beauty brand in the United States.

The PDRN Pink Collagen line embodies this dual expertise: technological innovation (protective capsules) and clinically proven ingredients (salmon PDRN, peptides, multi-weight HA). A philosophy that democratizes access to premium actives once reserved for Gangnam aesthetic clinics.

Discover the entire MEDICUBE range

Full INCI: Water, Glycerin, Niacinamide, Methylpropanediol, Propanediol, 1,2-Hexanediol, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glycereth-26, Arginine, Butylene Glycol, Ethylhexyl Palmitate, Cetearyl Alcohol, Carbomer, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Simethicone, Eclipta Prostrata Extract, Ethylhexylglycerin, Adenosine, Polyacrylate-13, Sodium DNA, Disodium EDTA, Melia Azadirachta Leaf Extract, Polyisobutene, Hydrolyzed Sclerotium Gum, Glyceryl Stearate, Moringa Oleifera Seed Oil, Polysorbate 20, Sorbitan Isostearate, Sodium Hyaluronate, Glutathione, Octyldodecanol, Hydroxypropyltrimonium Hyaluronate, Salmon Egg Extract, Hydrogenated Lecithin, Ceramide NP, Cyanocobalamin, Thioctic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen Extract, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Pentapeptide-4, Hydrolyzed Sodium Hyaluronate, Palmitoyl Hexapeptide-12.

Key active ingredients explained:

• Sodium DNA (PDRN) — Salmon DNA derivative, biocompatible with human skin, stimulates regeneration.
• Niacinamide (3rd position) — Brightening vitamin B3, barrier repair, anti-inflammatory.
• Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate — Hydration cascade from the surface film to the deeper layers.
• Salmon Egg Extract — Source of EGF, epidermal growth factor.
• Glutathione + Thioctic Acid (Alpha-Lipoic Acid) — Powerful antioxidants, brightening, anti-free radicals.
• Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Palmitoyl Hexapeptide-12 — Signal peptides that activate collagen synthesis and smooth fine lines.
• Ceramide NP — Lipid identical to those in the skin barrier, restores intercellular cement.
• Adenosine — Anti-wrinkle ingredient recognized by the Korean FDA, stimulates collagen production.
• Cyanocobalamin (Vitamin B12) — Soothing, anti-redness, cell regenerating.

Formula without synthetic fragrance, essential oils, parabens, or sulfates. Non-comedogenic. pH balanced to respect the skin’s acid mantle (manufacturer information).