REJURAN Turn Over Ampoule Dual Effector — Sérum PDRN Régénération Cellulaire

This ampoule concentrates the best of Korean dermocosmetics around scientifically proven regenerating active ingredients.

c-PDRN® 5000 ppm (Polydeoxyribonucleotide): purified wild salmon DNA fragment produced through a patented process. Stimulates fibroblasts to restart collagen and elastin synthesis in the dermis, visibly improves skin density, and accelerates the repair of micro-lesions. 97% biocompatible with human DNA.

Ceramide NP (N-stearoyl phytosphingosine): biomimetic ceramide that strengthens the lipid cohesion of the skin barrier. Limits transepidermal water loss and protects against environmental aggressions.

Niacinamide (Vitamin B3): regulates pigmentation by inhibiting melanosome transfer, refines skin texture, tightens enlarged pores.

Adenosine : anti-aging active recognized by the KFDA. Smooths fine lines by promoting endogenous hyaluronic acid production and improving skin elasticity.

Sodium Hyaluronate : low molecular weight form of hyaluronic acid that penetrates deeper to hydrate subcutaneous layers and provide long-lasting plumping.

Bisabolol : chamomile extract, soothing and anti-inflammatory. Calms redness and reduces discomfort in sensitive skin.

☀️ Morning routine

1. Cleanse your face, then apply your usual toner to balance the pH.
2. Dispense 3 to 5 drops of the ampoule into your palm. Warm it slightly between your hands.
3. Apply to the entire face, neck, and décolleté by gently patting to promote absorption — avoid the immediate eye area.
4. Wait 30 seconds for the serum to fully absorb before layering your moisturizer.
5. Finish with a sunscreen of at least SPF 30 (PDRN accelerates cell renewal, so increased photosensitivity).

🌙 Evening routine

1. Same protocol as in the morning: double cleanse, toner, then 3-5 drops of ampoule.
2. If your skin tolerates it well, you can alternate with a mild retinol (Monday-Wednesday-Friday ampoule alone, Tuesday-Thursday retinol).
3. Seal with a nourishing cream to support nighttime regeneration.

The ampoule can also be applied to the backs of the hands to reduce pigmentation spots and enhance skin fineness.

This ampoule is designed for specific profiles seeking a measurable regenerating effect:

• Mature skin (35 years and older) : loss of firmness, established wrinkles, dull complexion, lack of bounce.
• Skin that has undergone dermatological treatments : post-peeling, post-laser, post-microneedling — PDRN accelerates healing and reduces inflammation.
• Skin marked by time or sun exposure : brown spots, uneven texture, visible pores, compromised elasticity.
• Dry and dehydrated skin seeking deep hydration combined with long-lasting reparative action.
• Skin looking for anti-aging prevention from 28-30 years old: you anticipate metabolic slowdown without waiting for visible signs.

Avoid if:

• Known allergy to salmon-derived products or fish proteins.
• Open wounds, active eczema, uncontrolled dermatitis.
• Extremely reactive skin (test on the forearm for 48 hours before facial application).

The results unfold according to a precise timeline, calibrated to the epidermal renewal cycle:

From the first application: immediate comfort sensation, better hydrated skin, smooth texture to the touch.

After 2 weeks of twice-daily use: visible improvement in skin density, brighter complexion, softened expression lines (according to a clinical study by the Korea Institute of Dermatological Science on 22 volunteers).

After 4 weeks: restored firmness, improved elasticity, refined pores, overall more even texture. Post-acne or post-aesthetic treatment scars gradually fade.

After 8 weeks: lasting cumulative effects — strengthened skin barrier, increased resistance to environmental aggressions, visibly rejuvenated skin.

This is not an instant transformation: it is a methodical reconstruction, layer by layer.

What is DOT Dual Effect technology?

It is REJURAN's patented system that combines c-PDRN and Ceramide NP in a dual-action formulation: PDRN stimulates deep cellular regeneration, while ceramide repairs and strengthens the surface lipid barrier.

Can I use this ampoule after an aesthetic treatment (peeling, laser, microneedling)?

Yes, it is even recommended. c-PDRN has historically been used in dermatological clinics to accelerate post-procedure healing. Wait 24-48 hours after the treatment according to medical advice, then gradually incorporate the ampoule.

Is the salmon smell noticeable?

No. PDRN undergoes thorough purification that eliminates any odor. The ampoule has a neutral, slightly vegetal scent thanks to botanical extracts (licorice, calendula, blackberry).

How long does it take to see results on established wrinkles?

Expect 4 to 6 weeks of consistent use morning and evening. Fine lines fade faster (2-3 weeks), while deep wrinkles require at least 8 weeks to see significant smoothing.

Can I combine this ampoule with retinol or an exfoliating acid?

Yes, but gradually. If you are starting out: alternate one evening with ampoule alone, one evening with retinol. Once your skin is accustomed (4-6 weeks), you can layer: ampoule first, then retinol 10 minutes later. Avoid combining with strong acids (AHA/BHA > 10%) on the same evening.

Should it be stored in the refrigerator?

It is not mandatory, but recommended if you live in a hot or humid climate. Cold prolongs the stability of PDRN and provides a soothing/decongesting effect upon application. Keep it away from direct light.

REJURAN is not a cosmetic brand like the others: it is a South Korean laboratory historically specialized in regenerative medicine and clinical aesthetics. Before arriving in our bathrooms, REJURAN was the domain of dermatologists and leading clinics in South Korea, where PDRN injections (called "Rejuran Healer") became the standard for restoring damaged skin, post-laser, or simply slowing aging by stimulating endogenous collagen production.

The brand developed a patented process — c-PDRN® — that purifies and concentrates wild salmon DNA fragments to maximize their biocompatibility and regenerative activity. Building on this clinical success, REJURAN launched its consumer cosmetic line to democratize access to this technology without the need for injections.

Today, REJURAN stands as the global pioneer of topical PDRN: a scientific approach, without marketing hype, that appeals to demanding skincare enthusiasts as well as healthcare professionals.

Discover the entire REJURAN range

Complete INCI list:

Rubus Fruticosus (Blackberry) Leaf Extract, Glycyrrhiza Glabra (Licorice) Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Vaccinium Angustifolium (Blueberry) Fruit Extract, Morus Nigra Fruit Extract, Arbutin, Butylene Glycol, Glycerin, Polysorbate 20, Hydrolyzed DNA, Gerotine/Hydrolyzed DNA (c-PDRN®), Sodium Hyaluronate, Carbomer, Xanthan Gum, Adenosine, Tocopheryl Acetate, Niacinamide, Bisabolol, PEG-6, Water, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, 1,2-Hexanediol, Dipropylene Glycol, Sodium Chloride, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide NP, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol.

Formula free from parabens, sulfates, mineral oils, heavy silicones. Not tested on animals. Suitable for sensitive skin subject to prior patch testing.

Key active ingredients (c-PDRN, Ceramide NP, Niacinamide, Adenosine) are present at functional concentrations to ensure measurable efficacy. Botanical extracts (blackberry, licorice, calendula, blueberry) provide additional antioxidant and soothing support.