AESTURA Regederm365 Skin Tightening Capsule Serum

The Derma Tightening Barrier Capsules™ (105,000 PPM) form the core of this clinical formula. Each pump releases micro-capsules that burst upon contact with the skin, delivering a trio of encapsulated anti-aging actives: ceramides (Hydroxypropyl Bispalmitamide MEA, a ceramide analogue), collagen and vitamin C derivative. This encapsulation technology protects the actives from oxidation and ensures gradual penetration into the epidermis.

The Niacinamide (vitamin B3) is dosed at 10%, a clinical concentration that regulates sebum secretion responsible for pore laxity. This versatile active evens skin tone, strengthens the skin barrier, and reduces signs of premature aging — all without irritation thanks to the presence of soothing barrier capsules.

Thehyaluronic acid (Sodium Hyaluronate) maintains hydration with its ability to hold up to 1000 times its weight in water. Combined with glycerin and mannitol (a humectant sugar alcohol with antioxidant properties), it plumps the skin texture and smooths dehydration fine lines.

☀️ Morning routine

1. After cleansing and toner, pump one press.
2. Warm the serum between your palms to burst the visible capsules.
3. Apply all over the face with upward massages, focusing on the T-zone and enlarged pores.
4. Wait 30 seconds for full absorption before your moisturizer.
5. Always finish with sun protection (niacinamide can increase sensitivity).

🌙 Evening routine

1. Repeat the same protocol after double cleansing and toner.
2. If you use retinol or pure vitamin C, alternate nights or wait 10 minutes between layers (the serum has passed compatibility tests but monitor your tolerance).
3. Seal with a barrier cream to maximize the effect of the night capsules.

Concerned skin types:

• Epidermis with accelerated aging — especially sensitive skin that loses firmness prematurely, often weakened by excessive use of active ingredients
• Enlarged and visible pores — caused by excessive sebum production or loss of periorificial elasticity
• Dull complexion with fine lines — lacking tone and showing early signs of sagging (nasolabial folds, less defined oval)
• Post-aggressive routine — skin that has compromised its barrier with poorly dosed AHA/BHA/retinol, requiring reconstruction while maintaining anti-aging action

Avoid if: confirmed allergy to ceramide derivatives or known intolerance to high-concentration niacinamide (test on forearm 48h prior).

From 7 days : elasticity around pores doubles (clinical measurement on 263 testers with sensitive skin), micro-capsules form a protective film that maintains hydration without an occlusive effect.

After 2 weeks : the number of visible pores decreases by 27.9% and their volume reduces by 40.4% (clinical study, Global Amore Mall). The complexion becomes more even thanks to the progressive depigmenting action of niacinamide.

Continuous use (4-8 weeks) : overall firmness improves, dehydration fine lines fade, the skin barrier is restored (confirmed by a test panel of 30 people with sensitive skin, hospital dermatology department). The face regains a firmer structure without loss of comfort.

What is the difference with the Atobarrier365 cream from the same brand?

Atobarrier365 capsules specialize in hydration-barrier (ceramides, cholesterol, fatty acids), while Regederm365 capsules add collagen and a vitamin C derivative to specifically target elasticity and aging. Both share a common barrier base, but Regederm is focused on anti-aging.

Can I use it with retinol or vitamin C on the same night?

Yes, the serum has passed compatibility tests with high-performance actives. However, for reactive skin, alternate nights or wait 10 minutes between applications. Start with 2-3 times per week if you are new to retinol.

Why 10% niacinamide, isn’t that irritating?

This concentration is clinical and effective against hyperséborrhea responsible for enlarged pores. Irritation is prevented by the Derma Tightening Barrier Capsules™ which form a protective shield on the epidermis. The product passed a panel test on 30 sensitive people without reaction.

Are the capsules visible in the bottle normal?

Absolutely. These are micro-capsules of encapsulated actives (105,000 PPM). They burst upon massage on the skin, gradually releasing ceramides, collagen, and vitamin C. Shake the bottle gently before use to disperse them well.

How long does a 30 ml bottle last?

With morning and evening use (1 pump per application), expect about 6-8 weeks. If you use it only in the evening, you can reach 3 months. One pump is enough for the entire face thanks to the fluid texture.

Can I apply it around the eyes?

The serum is formulated for the entire face but remains gentle. Avoid the mobile eyelid (risk of migration). For the eye contour, AESTURA offers a dedicated serum, Regederm365 Retinoid Eye Serum, more suitable for this delicate area.

AESTURA is the dermocosmetic branch of the Amorepacific group, founded in 1982 under the name Pacific Pharmaceuticals. The name "AESTURA" derives from the Latin aestuarium (estuary), symbolizing the meeting point between pharmaceutical research and cosmetics, like a fertile delta.

Since 2008, the Atobarrier cream — initially sold exclusively in dermatology clinics — has built the brand's reputation among South Korean dermatologists. AESTURA holds the title of the No.1 cosmetic brand sold in dermatology clinics for 10 consecutive years (Korea Consumer Agency, 2016-2025) and equips 100% of South Korea's tertiary general hospitals.

The Regederm365 range, launched in retail in 2020, incorporates barrier capsule technology with an added anti-aging dimension (the suffix "365" denotes daily use, outside hospital protocols). Each formula is co-developed with dermatologists and tested on panels of sensitive skin before commercialization.

Discover the entire AESTURA range

Full INCI: Water, Butylene Glycol, Niacinamide, Glycerin, Dimethicone, 1,2-Hexanediol, Hydrogenated Polydecene, Stearic Acid, Hydroxypropyl Bispalmitamide MEA (ceramide analogue), Mannitol, Dimethicone/Vinyl Dimethicone Crosspolymer, Polymethylsilsesquioxane, Carbomer, Tromethamine, Sodium Hyaluronate, Xanthan Gum, Ethylhexylglycerin, Sodium Stearoyl Glutamate, Adenosine, Disodium EDTA, Cholesterol, Theobroma Cacao (Cocoa) Extract, Simmondsia Chinensis (Jojoba) Seed Oil, Butyrospermum Parkii (Shea) Butter, Phytosphingosine, Hydrolyzed Extensin, Beta-Glucan, Ceramide NP, Hydrogenated Lecithin, Tocopherol (Vitamin E).

Key points: 35 ingredients in total, including 29% of natural origin. Vegan formula, free from drying alcohol, fragrance, parabens, and sulfates. Physiological pH (not specified for this serum but AESTURA generally formulates between 4.5-5.5). The capsules contain the barrier complex (ceramides, cholesterol, fatty acids) + collagen (plant-derived Hydrolyzed Extensin) + stabilized vitamin C (not explicitly listed but mentioned on the official website as a "vitamin C derivative").